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目的 :探讨善得定对腹腔化疗时淋巴药物浓度的调节作用。方法 :大肠癌患者行卡铂腹腔化疗时联合应用善得定 ,观察腹腔淋巴结、门静脉铂浓度变化。结果 :应用善得定后腹腔淋巴铂浓度 2小时后提高 ,而门静脉铂浓度变化不大。结论 :善得定可诱导卡铂腹腔淋巴化疗。
OBJECTIVE: To investigate the regulative effect of Zenadine on the concentration of lymphatic drugs during intraperitoneal chemotherapy. Methods: Colorectal cancer patients were treated with carboplatin intraperitoneal chemotherapy combined with good set to observe the changes of intra-abdominal lymph node and portal vein platinum concentration. Results: After intraperitoneal lymphatic placental concentration was increased after 2 hours, the concentration of platinum in the portal vein did not change much. Conclusion: Good day set can induce carboplatin peritoneal lymphatic chemotherapy.