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《中国药典》1990年版一部在附子用法与用量中仅规定了用量,而忽视了附子的用法。附子,因含有乌头碱而有毒,久煎可使乌头碱分解为乌头次碱,进而分解为乌头原碱。其毒性只及原来的1/200。附子久煎不仅能降低毒性,还能增强强心作用。近年来,有关附子不良反应屡有报告,其原因与用量过大,炮制不当,煎煮失法或机体对该药敏感性的差异有关。
The 1990 Pharmacopoeia of the Chinese Pharmacopoeia only stipulated the dosage in the usage and dosage of aconite, but ignored the use of aconite. Aconite, which is toxic due to aconitine, can be decomposed into aconitine by decocting for a long time and then decomposed into Aconitum. Its toxicity is only 1/200 of the original. Fuzi fried for a long time can not only reduce toxicity, but also enhance the cardiac effect. In recent years, there have been repeated reports of adverse reactions to Aconite. The reasons are related to the excessive use of Aconite, inappropriate processing, and the difference in the sensitivity of decocting or the body’s sensitivity to the drug.