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目的:观察DDP联合5蛳Fu腹腔内化疗治疗恶性腹水的治疗效果。方法:45例恶性腹水患者采用DDP联合5蛳Fu腹腔内化疗,腹穿尽量抽尽腹水,以含DDP60mg~100mg的生理盐水溶液注入,继之5蛳Fu1000mg~1500mg,地塞米松10mg注入腹腔。常规水化、利尿、补钾3d。用药间隔至少在3周以上。结果:总有效率82.2%,其中CR33.3%,PR48.9%。毒副反应主要为胃肠道反应、腹痛、骨髓抑制、血清肌酐谷丙转氨酶升高,患者均能耐受。结论:DDP联合5蛳Fu腹腔化疗治疗恶性腹水疗效较满意,且经济方便,为一种安全有效、适用于基层医院采用的实用性治疗手段。
Objective: To observe the therapeutic effect of DDP combined with 5 蛳 Fu intraperitoneal chemotherapy for malignant ascites. Methods: Forty-five patients with malignant ascites were treated with intraperitoneal chemotherapy with DDP combined with 5-Fu and abdominal cavity. The ascites was drained as much as possible. The rats were infused with DDP (60mg ~ 100mg) and saline followed by 5% Fu1000mg ~ 1500mg and dexamethasone 10mg. Routine hydration, diuretic, potassium supplement 3d. Medication interval at least 3 weeks or more. Results: The total effective rate was 82.2%, of which CR33.3% and PR48.9%. Toxic side effects mainly gastrointestinal reactions, abdominal pain, bone marrow suppression, elevated serum creatinine alanine aminotransferase, patients can tolerate. Conclusion: DDP combined with 5 蛳 Fu intraperitoneal chemotherapy for malignant ascites treatment more satisfactory, and economical and convenient, is a safe and effective, suitable for primary hospitals to adopt a practical treatment.