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目的 为服药方便 ,将咽炎饮汤剂改为冲剂 ,做两种剂型的主要药效试验。方法 采用临床常见的金黄色葡萄球菌、大肠杆菌、B族链球菌、D族链球菌、肺炎双球菌、表皮葡萄球菌、克雷杆菌做体外抑菌试验及选小鼠做体内抑菌试验 ;选健康家兔做皮下注射脱脂牛奶的解热作用试验 ;做醋酸溶液致小鼠疼痛扭体次数试验。结果 两种剂型在体外均有抑菌作用 ,其中中、大剂量对体内金黄色葡萄球菌、表皮葡萄球菌有抑制。两剂型均能降低发热家兔的体温及减少醋酸溶液致小鼠扭体次数。结论 咽炎饮冲剂和汤剂的主要药效学作用相似 ,两种剂型的相同剂量组之间差异无显著性
Objectives To facilitate the use of drugs, the pharyngitis decoction decoction was changed to granules, the main efficacy trials of the two formulations. Methods In vitro antibacterial tests using Staphylococcus aureus, Escherichia coli, Group B Streptococcus, Group D Streptococcus, Streptococcus pneumoniae, Staphylococcus epidermidis, and Streptococcus spp. Healthy rabbits were given the antipyretic effect of subcutaneous injection of skim milk; acetic acid solution was used to test the number of times of pain and twist in mice. Results Both formulations had antibacterial effects in vitro, with medium and high doses inhibiting Staphylococcus aureus and Staphylococcus epidermidis in vivo. Both doses can reduce the body temperature of rabbits and reduce the number of writhing caused by acetic acid solution. Conclusion The main pharmacodynamic effects of yanyan drink granules and decoction are similar, and there is no significant difference between the same dose groups of the two dosage forms.