近年来大量的研究证明 ,野生型Ｐ5 3基因是广泛存在于人组织细胞中的抑癌基因 ,Ｐ5 3基因突变与缺失是肺癌发生的重要原因之一[1] 。但以往研究大多为固定肺癌标本分析 ,本研究通过对可疑肺癌患者同步送检痰液细胞学及Ｐ5 3基因分析 ,初步显示 ,同步进行痰病理学与Ｐ5 3检测有 In recent years, a large number of studies have shown that the wild-type P5 3 gene is a tumor suppressor gene widely present in human tissue cells. P53 gene mutation and deletion is one of the important causes of lung cancer [1]. However, most of the previous studies were for the analysis of fixed lung cancer specimens. This study was conducted through the simultaneous examination of sputum cytology and P53 gene analysis in suspicious patients with lung cancer. It was initially shown that synchronous pathophysiology and P53 detection were available.