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膜性肾病 (MCN)是免疫介导的肾小球疾病 ,由抗体与抗原形成免疫复合物 ,激活补体 ,导致肾小球肿瘤坏死因子(TNF-α)生成增多 ,尿 TNF-α也增多。研究发现已酮可可碱抑制或减少 TNF-α的合成。该前瞻性试验评估此药 1.2 g/d对原发性 MGN病人蛋白尿的影响。 10例经组织学证实为原
Membranous nephropathy (MCN) is an immune-mediated glomerular disease that forms an immune complex with antibodies and activates complement, leading to an increase in glomerular tumor necrosis factor (TNF-α) production and an increase in urinary TNF-α. It has been found that pentoxifylline inhibits or reduces the synthesis of TNF-α. This prospective trial evaluated the effect of 1.2 g / d on proteinuria in patients with primary MGN. 10 cases confirmed by the original histology