一、前言远在20世纪初期Ehrlich就已经对抗代谢物有一些初步认识,后来Michaelis及Quastel等分别在研究蔗糖转化酶与α葡萄糖苷酶、琥珀酸脱氢酶发现有许多现象与抗代谢物的基本理论有关。Woolley等曾于1938年发现菸酸(一),β-乙酰吡啶(二),吡啶-3-磺酸(三)的化学结构相近,若以后两种化合物治疗狗的菸酸缺乏症,结果在正常 First, the foreword Ehrlich far in the early twentieth Century have had some preliminary understanding of metabolites, and later Michaelis and Quastel, respectively, in the study of sucrose invertase and α-glucosidase, succinate dehydrogenase found in many phenomena with anti-metabolites Basic theory. In 1938, Woolley et al. Found that the chemical structures of niacin (A), β-acetylpyridine (B), and pyridine-3-sulfonic acid (C) are similar, and if the latter two compounds are used to treat niacin deficiency in dogs, normal