甲氨苯脒是近年国外出现的一种新型广谱抗蠕虫新药,我所对1980年引进合成以来已进行较系统的药理研究和临床观察,证明该药对钩虫有显著疗效,且毒性低、安全范围广。为进一步了解甲氨苯脒有无致突变作用,我们进行了小白鼠微核实验,实验结果可见甲氨苯脒无论大中小各剂量组,其含有微核的嗜多染红细胞数均在5‰以下,与正常对照组 Metamidine is a new broad-spectrum antihelminthic drug which appeared in recent years in our country. Since the introduction of synthesis in 1980, it has carried out more systematic pharmacological studies and clinical observations, which proved that the drug has a significant curative effect on hookworm and has low toxicity. Wide range of safety. In order to further understand whether methylamidine mutagenic effect, we conducted a mouse micronucleus test, the experimental results can be seen metamizumab dose group, medium and micronuclei contain polyenzymatic red cells in 5 ‰ Below, with the normal control group