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目的:研究原生痛的急性毒性和镇痛抗炎作用。方法:以Bliss法计算原生痛单次ig小鼠的LD50;以小鼠扭体法、热板法及大鼠压痛法测定其镇痛作用;以角叉菜胶致大鼠足肿胀模型、小鼠腹腔毛细血管通透性模型及佐剂致大鼠关节炎模型观察原生痛抗炎作用。结果:原生痛LD50为30.10 g·kg-1;95%的可信限为25.85～34.66 g·kg-1。小鼠0.184,0.369g·kg-1和大鼠0.184 g·kg-1以上剂量,对化学刺激性、热刺激性或机械刺激性疼痛均有明显的镇痛作用。对非特异急性炎症模型或佐剂性关节炎模型也有显著的抗炎作用。结论:原生痛一次性给药镇痛作用突出,且有较宽的安全窗,适用于风湿性关节炎等病症疼痛明显者缓急之用。
Objective: To study the acute toxicity and analgesic and anti-inflammatory effects of primary pain. Methods: The LD50 of single ig mice with primary pain was calculated by Bliss method. The analgesic effect was evaluated by writhing method, hot plate method and rat tenderness method. The carrageenan-induced rat paw swelling model was small Rat abdominal capillary permeability model and adjuvant - induced arthritis model in rats observed the pain of anti - inflammatory effects. Results: The LD50 of native pain was 30.10 g · kg-1; 95% confidence interval was 25.85 ~ 34.66 g · kg-1. Mice 0.184, 0.369g · kg-1 and 0.184g · kg-1 more than the dose of chemical irritant, thermal irritant or mechanical irritant pain were significant analgesic effect. There is also a significant anti-inflammatory effect on nonspecific acute or adjuvant arthritis models. CONCLUSION: The primary analgesic effect of primary pain is outstanding and has a wide safety window. It is suitable for the patients with obvious pain and other diseases such as rheumatoid arthritis.