环境的、实验的及临床的资料表明:长期小剂量摄入氟化物与癌症的产生有关。环境方面的证据:在开采氟石地区,肺癌发病率通常很高。例如在1933～1961年纽芬兰St. Lawrence的矿工中21.8%的雇员,36.2%的井下矿工死于肺癌。该矿粉尘中含62%氟石和19%石英,但其氟化物的作用程度不清楚。苏联科学家发现在两个铝厂附近癌症死亡率高于7公里外的大气污染较轻的对照区。与莫斯科相比这两个工厂区的癌症死亡率极高。研究者把致癌活性的主要作用归因于大气中的3,4-二甲基苯丙蒽。据加拿大Cecilioni观察,钢铁厂附近居的肺癌发病率为65/10万,距工厂很远城市居民的仅为12/10万,安大略省和加拿大全境为23/10万。然而 Environmental, experimental and clinical data indicate that long-term, low-dose fluoride exposure is associated with cancer. Environmental Evidence: In the mining of fluorite areas, the incidence of lung cancer is usually high. For example, 21.8% of miners in St. Lawrence, Newfoundland from 1933 to 1961, and 36.2% of miners died of lung cancer. The mine dust contains 62% fluorite and 19% quartz, but the extent of its fluoride effect is not clear. Soviet scientists found that in the vicinity of two aluminum smelters cancer mortality is higher than 7 km outside the air pollution control area. The cancer rates in these two factories are very high compared to Moscow. The researchers attribute the major role of oncogenic activity to 3,4-dimethylbenzofuran in the atmosphere. According to Cecilioni of Canada, the incidence of lung cancer in the vicinity of steel mills is 65/10 million, only 12/10 of urban residents are very far away from the factory, and 23/10 of all in Ontario and Canada. however