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5. Overexpression of a dominant-negative mutant of SIRT1 in mouse heart causes cardiomyocyte apoptosis

Overexpression of a dominant-negative mutant of SIRT1 in mouse heart causes cardiomyocyte apoptosis

来源 :中国科学：生命科学英文版 | 被引量 : 0次 | 上传用户：zhaorongjian

【摘 要】

：

SIRT1,a mammalian ortholog of yeast silent information regulator 2(Sir2),is an NAD+-dependent protein deacetylase that plays a critical role in the regulation o

【作 者】

：

MU WenLi ZHANG QingJun TANG Xi 

【机 构】

：

StateKeyLaboratoryofMedicalMolecularBiology

【出 处】

：

中国科学：生命科学英文版

【发表日期】

：

2014年9期

【关键词】

：

心肌细胞凋亡 转基因小鼠 心脏发育 过度表达 显性 衰竭 突变体 去乙酰化酶 deacetylase SIRT1 apoptosis heart failure 

【基金项目】

：

We acknowledge Dr. Liu ZhiPing from University of Texas Southwestern Medical Center for important reading of the manuscript. We are grateful to Prof. Zhang YouYi, Dr. Xiao Hart from Peking University

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SIRT1,a mammalian ortholog of yeast silent information regulator 2(Sir2),is an NAD+-dependent protein deacetylase that plays a critical role in the regulation of vascular function.The current study aims to investigate the functional significance of deacet

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