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目的分析连续负荷量冻干重组人脑利钠肽(新活素)治疗心力衰竭的短期疗效与血清脑钠肽(BNP)、糖类抗原125(CA125)水平的相关性。方法选取120例心力衰竭住院患者,给予连续负荷量新活素治疗。检测所有患者入院后及治疗结束后血清BNP、CA125水平。结果治疗后血清BNP、CA125水平均低于治疗前(P<0.05);治疗后24、48和72h的短期疗效与治疗前的BNP水平均呈负相关,相关系数分别为-0.357、-0.102、-0.293;与治疗前的CA125水平均呈负相关,相关系数分别为-0.277、-0.234、-0.382。结论采用连续负荷量新活素治疗心力衰竭,可降低血清BNP、CA125水平,且治疗的短期疗效与BNP和CA125水平呈负相关。
Objective To analyze the correlation between the short-term curative effect of continuous loading of recombinant human brain natriuretic peptide (nesiritin) and serum brain natriuretic peptide (BNP), carbohydrate antigen 125 (CA125). Methods A total of 120 hospitalized patients with heart failure were enrolled and given continuous intravenous injection of survivin. All patients after admission and after treatment serum BNP, CA125 levels. Results After treatment, the levels of serum BNP and CA125 were lower than those before treatment (P <0.05). The short-term effects at 24, 48 and 72 hours after treatment were negatively correlated with the levels of BNP before treatment, the correlation coefficients were -0.357, -0.102, -0.293; and the level of CA125 before treatment were negatively correlated, the correlation coefficients were -0.277, -0.234, -0.382. Conclusions The use of continuous loading of SWNT in the treatment of heart failure can reduce the serum BNP and CA125 levels, and the short-term curative effect is negatively correlated with the levels of BNP and CA125.