下肢缺血性疾病是因动脉狭窄或闭塞而引起的一系列疾病,严重影响患者生活质量甚至危及生命。对此类疾病的主要治疗方法包括药物治疗、手术和介入治疗等。随着分子生物学的进展,血管基因治疗和自体干细胞移植为下肢缺血性疾病的治疗带来了新的希望,显示出广阔的应用前景。 Lower extremity ischemic disease is a series of diseases caused by stenosis or occlusion of the artery, seriously affecting the quality of life of patients and even life-threatening. The main treatment for such diseases include medical treatment, surgery and interventional therapy. With the progress of molecular biology, vascular gene therapy and autologous stem cell transplantation have brought new hope for the treatment of ischemic diseases of the lower limbs, and have shown broad application prospects.