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目的：探讨胃癌中ＥＲ与ｃ－ｍｙｃ癌基因蛋白表达的关系。方法：采用免疫组织化学链霉菌亲生物素－过氧化酶（ＳＰ法检测９１例胃癌中ＥＲ、ｃ－ｍｙｃ ｐ６２的表达。结果： ＥＲ与ｃ－ｍｙｃ ｐ６２在胃癌中的阳性表达率各为３８％（３５／９１）与５１％（４６／９１）。而在６１例分化不良的胃癌分别是：低分化腺癌４３％（１３／３０）与４７％（１４／３０），未分化癌５３％（８／１５）与６０％（９／１５），粘液癌６３％（５／８）与５０％（４／８），印戒细胞癌７５％（６／８）与７５％６／８），ＥＲ与ｃ－ｍｙｃ蛋白共同阳性２２例，共同阴性１８例，配对卡方检验，两者表达有明显相关性（Ｐ＜ ０．０５并且，Ｂｏｒ－ｒｍａｎｎ Ⅲ、Ⅳ型、淋巴结转移者阳性表达率皆分别显著高于Ⅰ、Ⅱ型及无转移者（Ｐ＜ ０．０５。结论：ＥＲ与ｃ－ｍｙｃ的表达与胃癌的浸润转移有关。在分化不良的胃癌中，ＥＲ与ｃ－ｍｙｃ表达存在显著相关性，提示ＥＲ作为一种反式激活因子可增强ｃ－ｍｙｃ癌基因表达，是促进细胞增殖的分子机理之一。
Objective: To investigate the relationship between ER and c-myc oncogene protein expression in gastric cancer. METHODS: Immunohistochemical Streptomyces protobiotin-peroxidase (SP method was used to detect the expression of ER and c-myc p62 in gastric cancer. Results: The positive expression rates of ER and c-myc p62 in gastric cancer were 38% (35/91) and 51% (46/91), while in 61 cases of poorly differentiated gastric cancers: poorly differentiated adenocarcinomas were 43% (13/30) and 47% (14/30), undifferentiated carcinomas. 53% (8/15) and 60% (9/15), 63% (5/8) and 50% (4/8) of mucinous carcinoma, 75% (6/8) and 75% 6 of signet ring cell carcinoma /8) ER and c-myc protein were positive in 22 cases and negative in 18 cases. Paired chi-square tests showed significant correlation between the two expressions (P<0.05) and Bor-rmann III, IV, The positive expression rates of lymph node metastasis were significantly higher than those of type I, II, and non-metastasis, respectively (P<0.05). Conclusions: Expression of ER and c-myc and stomach Infiltration and metastasis are involved.In poorly differentiated gastric cancer, there is a significant correlation between ER and c-myc expression, suggesting that ER as a transactivator can enhance the expression of c-myc oncogene and is one of the molecular mechanisms that promote cell proliferation. .