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用急性低氧肺动脉高压模型（猪）、在Ｓｗａｎ－Ｇａｎｚ导管和动脉导管临护下，低氧前后及用尼群地平（ＮＴ，０．１ｍｇ／ｋｇ），巯甲丙脯酸（ＣＰ，７ｍｇ／ｋｇ）静注前后，观察了体、肺循环血流动力学指标及动脉血浆内皮素（ＥＴ），血栓素（ＴＸＡ２）及前列环素（ＰＧＩ２）的稳定代谢产物ＴＸＢ２和ＰＧＦ１ａ含量变化。结果表明，低氧后平均肺动脉压（ｍＰＡＰ）２．９±０．２对４．１±０．２ｋＰａ，ＥＴ１１６１．７±２１．９对２２３．２±２８．０ｐｇ／ｍｌ，右心每搏做功指数（ＲＶＷＩ）６２．２±３．１对８５．４±２．９ｍＪ／Ｍ２，ＴＸＢ２１２４．８±２０．５对１７８．０±１８．４ｐｇ／ｍｌ均较低氧前显著升高（Ｐ＜０．０５）。静脉注入ＮＴ及ＣＰ后，ｍＰＡＰ，（从４．１３±０．２下降至３．５±０．２ｋＰａ），ＲＶＷＩ（８５．４±２．９对７６．５±２．８ｍＪ／Ｍ２），左心每搏作动指数（ＬＶＷＩ）由７１２．０±７．２对５０７．２±６．１ｍＪ／Ｍ２，ＥＴ１（２２３．２±２８．０对１７９．０±２０．９ｐｇ／ｍｌ）均显著下降（Ｐ＜０．０５）。药物作用持续时间超过６ｈ。体循环血压下降，Ｐ＜０．０５（Ｂｐ由２２．０±０．７对１７．６±１．４ｋＰ?
Acute hypoxic pulmonary hypertension (pigs) were treated with Swan-Ganz catheter and arterial catheter, hypoxia before and after treatment with nitrendipine (NT, 0.1 mg / kg), captopril / Kg), the body and pulmonary circulation hemodynamics and the content of TXB2 and PGF1a in the stable metabolites of ET, TXA2 and PGI2 were observed before and after intravenous injection. The results showed that mean hypoxic pulmonary pressure (mPAP) 2.9 ± 0.2 vs 4.1 ± 0.2kPa, ET1161.7 ± 21.9 vs 223.2 ± 28.0pg / ml, right ventricular stroke The work index (RVWI) 62.2 ± 3.1 vs 85.4 ± 2.9 mJ / M2, TXB2124.8 ± 20.5 vs 178.0 ± 18.4 pg / ml were significantly lower than those before hypoxia (P <0.05). After intravenous injection of NT and CP, mPAP (from 4.13 ± 0.2 to 3.5 ± 0.2 kPa), RVWI (85.4 ± 2.9 vs 76.5 ± 2.8 mJ / M2), Left ventricular stroke index (LVWI) increased from 712.0 ± 7.2 to 507.2 ± 6.1 mJ / M2, ET1 (223.2 ± 28.0 vs 179.0 ± 20.9 pg / ml) Significantly decreased (P <0.05). Duration of drug over 6h. The systemic blood pressure decreased, P <0.05 (Bp from 22.0 ± 0.7 vs 17.6 ± 1.4kP?