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目的探讨转化生长因子-β1在尘肺病发生中表达水平的变化。方法采用双抗体夹心ELISA法测定尘肺组、接尘组和对照组血清中(TGF-β1)含量。结果水泥生产场所中的粉尘浓度最高达97.2 mg/m3,各测试点的粉尘浓度平均值均超过容许限值,尘肺组TGF-β1水平(61.72 ng/ml)高于接尘组(30.61 ng/ml)和对照组(21.23 ng/ml),差异有统计学意义(P<0.01),接尘组与对照组差异无统计学意义(P>0.05)。结论血清中TGF-β1与尘肺发生有关,可以作为尘肺的生物学检测指标。
Objective To investigate the expression of transforming growth factor-β1 in pneumoconiosis. Methods Serum levels of TGF-β1 in pneumoconiosis group, control group and control group were determined by double antibody sandwich ELISA. Results The dust concentration in the cement production site was up to 97.2 mg / m3, and the average dust concentration in each test point exceeded the allowable limit. The level of TGF-β1 in pneumoconiosis group (61.72 ng / ml) was higher than that in dust exposure group (30.61 ng / ml) and control group (21.23 ng / ml), the difference was statistically significant (P <0.01). There was no significant difference between the dust control group and the control group (P> 0.05). Conclusion Serum TGF-β1 is associated with pneumoconiosis and can be used as a bioassay marker for pneumoconiosis.