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失重和地面模拟失重导致大鼠承重骨矿物质和羟脯氨酸含量减少以及生物力学性能减弱。已知维生素Ｃ（Ｖ．Ｃ）具有促进骨胶元合成的作用。因此探讨补充Ｖ．Ｃ对尾吊大鼠骨质的影响，对失重骨丢失防护措施的研究有一定意义。实验中，给用尾吊法模拟失重的ＳＤ种雄性大鼠（ｎ＝７）补充大剂量抗坏血酸（２５０ｍｇ／ｋｇ体重），２２ｄ后测定股骨及股软骨理化指标及生物力学参数。结果表明，补充Ｖ．Ｃ组大鼠股软骨的羟脯氨酸、灰分的含量和密度以及股骨的弹性载荷、最大应力和硬度均明显高于悬吊对照组。结果提示，大剂量补充抗坏血酸对尾吊大鼠股软骨的理化特性和股骨的生物力学性能有明显的改善作用。
Weightlessness and ground-based simulated weightlessness lead to reduced weight-bearing bone mineral and hydroxyproline content and diminished biomechanical properties in rats. Vitamin C (V.C) is known to promote collagen synthesis. So explore the supplement V. C on tail bone in rats with bone loss, loss of weight loss prevention measures of some significance. In the experiment, male SD rats (n = 7) were fed with high dose of ascorbic acid (250mg / kg body weight). The physical and biomechanical parameters of femur and femoral cartilage were measured after 22 days. The result shows that, supplement V. Hydroxyproline, ash content and density of femoral cartilage in C group and the elastic load, maximum stress and hardness of femoral cartilage in C group were significantly higher than those in control group. The results suggest that large doses of ascorbic acid can significantly improve the physicochemical properties of the femoral cartilage and the biomechanical properties of the femur in tail-suspended rats.