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多药耐药(MDR)是目前肿瘤治疗中面临的关键难点,也是临床化疗失败的主要原因.MDR指肿瘤细胞对一种化疗药物产生耐药性的同时,对其他结构和功能不同的化疗药物也产生交叉耐受的现象.耐药常见的一种机理是细胞内P-糖蛋白(P-gp)的过度表达,P-gp将进入肿瘤细胞的抗癌药物泵送出细胞外,从而降低细胞内的抗癌药物的浓度,使药物难以达到预期疗效.
Multidrug resistance (MDR) is currently the key challenge in the treatment of cancer, but also the main reason for the failure of clinical chemotherapy.MDR refers to tumor cells to a chemotherapeutic drug resistance, while other structures and functions of different chemotherapeutic drugs Also produce cross-tolerance phenomenon.A common mechanism of resistance is the intracellular P-glycoprotein (P-gp) overexpression, P-gp into the tumor cells of anti-cancer drugs pumped out of the cell, thereby reducing The concentration of anti-cancer drugs in the cell, making it difficult to achieve the desired drug efficacy.