组蛋白酶D是绝大多数真核细胞溶酶体内的主要成分之一,在正常生理条件下,参与细胞的生长调控,然而,当机体细胞微环境发生异常改变时,它能降解细胞间质、促进细胞分裂增殖和血管生成等功能。近年来,普遍认为,其表达失调与恶性肿瘤的复发和转移密切相关,且可能是肿瘤预后判断的一个生物标记,本文主要就其与恶性肿瘤的相关性进展加以综述。 Histone D is one of the major components of lysosomes in most eukaryotes. Under normal physiological conditions, histone D is involved in the regulation of cell growth. However, it can degrade interstitial cells when abnormal changes occur in the cell microenvironment, Promote cell division and proliferation and angiogenesis and other functions. In recent years, it is generally believed that the expression of dysregulation is closely related to the recurrence and metastasis of malignant tumors, and may be a biomarker for judging the prognosis of the tumor. This article mainly reviews the progress of its correlation with malignant tumors.