论文部分内容阅读
目的观察红花黄色素联合二甲双胍治疗早期糖尿病肾病(DN)的临床疗效及对患者血清NF-κB炎症信号通路的影响。方法选取2015年10月至2016年10月诊治的DN患者80例,随机分为对照组和观察组,每组40例,2组均接受常规治疗,对照组在常规治疗基础上口服盐酸二甲双胍治疗,观察组在对照组基础上静脉滴注红花黄色素。疗程均为2周。观察2组临床疗效及治疗前后血清NF-κB p50、p65 mRNA和蛋白表达、超敏C-反应蛋白(hsCRP)、肿瘤坏死因子α(TNF-α)、白介素-6(IL-6)水平变化。结果对照组和观察组总有效率分别为57.50%、87.50%,观察组总有效率较对照组显著提高,差异有统计学意义(P<0.05)。与治疗前比较,2组治疗后NF-κB p50、p65 mRNA和蛋白表达及hs-CRP、TNF-α、IL-6水平明显降低,且观察组上述指标降低程度优于对照组(P<0.05)。结论红花黄色素联合二甲双胍治疗早期糖尿病肾病疗效显著,其机制与抑制NF-κB炎症信号通路的活化及炎性因子释放有关。
Objective To observe the clinical efficacy of safflor yellow combined with metformin in the treatment of early diabetic nephropathy (DN) and its effect on serum NF-κB inflammatory signal transduction pathway. Methods Eighty patients with DN who were diagnosed and treated from October 2015 to October 2016 were randomly divided into control group and observation group, 40 cases in each group. Both groups received routine treatment. The control group was treated with metformin hydrochloride on the basis of routine treatment The observation group was treated with intravenous injection of safflower yellow pigment on the basis of the control group. The course of treatment is 2 weeks. The changes of serum levels of NF-κB p50, p65 mRNA and protein, hsCRP, TNF-α and IL-6 in two groups were observed before and after treatment. . Results The total effective rate was 57.50% in control group and 87.50% in observation group, and the total effective rate in observation group was significantly higher than that in control group (P <0.05). The levels of NF-κB p50, p65 mRNA and protein and the levels of hs-CRP, TNF-α and IL-6 in the two groups were significantly lower than those in the control group before treatment ). Conclusion Safflower yellow combined with metformin treatment of early diabetic nephropathy significant effect, its mechanism and inhibition of NF-κB activation of inflammatory signal transduction pathway and the release of inflammatory cytokines.