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作者为评价单次立体定向放疗的毒性,对用9MeV直线加速器治疗的133例病例的CT、MRI及临床资料进行回顾性分析。用Cox累计危险模式对病人的治疗参数、剂量——体积与放疗所致组织改变(水肿、局部血脑屏障破坏)相互关系进行分析。 全组女67例,男66例。年龄12～80岁(中位42岁),133例中135个病灶被照射(2例神经纤维瘤病1型和多发肿瘤治疗2次)。中位随访期28.1月(9.0～58.9月)。单个脑实质内病灶61例,单个
To evaluate the toxicity of single stereotactic radiotherapy, CT, MRI and clinical data of 133 cases treated with 9MeV linear accelerator were retrospectively analyzed. The Cox cumulative hazard model was used to analyze the interrelationship between the patient’s treatment parameters, dose-volume, and tissue changes (edema, local blood-brain barrier disruption) induced by radiotherapy. The whole group included 67 females and 66 males. Ages 12 to 80 years (median, 42 years old), 135 lesions were irradiated in 133 (2 neurofibromatosis type 1 and multiple tumor treatment 2 times). The median follow-up period was 28.1 months (9.0 to 58.9 months). Single brain parenchymal lesions in 61 cases, single