运用标准玻璃微电极技术，观察腺苷（Ado）及异两基肾上腺素（Iso）对豚鼠心房、心室肌细胞动作电位（AP）的影响及其相互作用。结果表明，Ado可缩短心房肌细胞动作电位时程（APD），对其膜静息电位（RP）、动作电位幅度（APA）及零相最大去极化速率（Vmax）无影响；对心室肌细胞，即使较高浓度Ado亦无明显影响。Iso可使心房、心室肌细胞APD延长，Ado可消除Iso的电生理作用。Ado的这些电生理作用均可被选择性腺苷A1受体拮抗体DPCPX所拮抗。 The standard glass microelectrode technique was used to observe the effects of adenosine (Ado) and iso-bitalrene (Iso) on the action potentials (APs) of atrial and ventricular myocytes in guinea pigs and their interactions. The results showed that Ado could shorten the action potential duration (APD) of atrial myocytes, and had no effect on the resting potential (RP), APA (APA) and maximal depolarization rate (Vmax) Cells, even at higher concentrations of Ado, had no significant effect. Iso can prolong APD of atria and ventricular myocytes, while Ado can eliminate the electrophysiological effects of Iso. These electrophysiological effects of Ado can be antagonized by the selective adenosine A1 receptor antagonist DPCPX.