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目的从血液流变学的角度对长期无症状高尿酸血症开展系统研究,为该症的临床处理提供参考依据。方法将20只SD大鼠随机平均分为空白对照组和模型组。通过对大鼠腹腔注射250 mg/(kg·d)氧嗪酸钾诱导8周无症状高尿酸血症模型,采血测量尿酸水平、血液流变学指标、氧化和抗氧化指标。结果模型组大鼠红细胞的聚集指数、破碎率、血清黄嘌呤氧化酶活性(XOD)、血浆纤维蛋白原、血液黏度显著升高,红细胞的取向指数、电泳率、血清超氧化物歧化酶活性(SOD)、活化部分凝血酶时间(APTT)和凝血酶原时间(PT)显著降低。结论无症状高尿酸血症水平下机体氧化应激增强,使大鼠红细胞流变特性发生不良变化,血液处于高黏高凝状态。研究结果提示临床诊治中应对无症状高尿酸血症正确认识并及时干预。
Objective To carry out a systematic study of long-term asymptomatic hyperuricemia from the perspective of hemorheology and provide a reference for the clinical treatment of this disease. Methods Twenty SD rats were randomly divided into blank control group and model group. The model of asymptomatic hyperuricemia was induced by intraperitoneal injection of 250 mg / (kg · d) oxynitrate into rats. Uric acid levels, hemorheological indexes, oxidation and antioxidation indexes were determined by blood sampling. Results The indexes of erythrocyte aggregation, fragmentation rate, XOD, plasma fibrinogen and blood viscosity were significantly increased, the orientation index of erythrocytes, electrophoresis rate, serum superoxide dismutase activity ( SOD), activated partial thromboplastin time (APTT) and prothrombin time (PT) decreased significantly. Conclusions Asymptomatic hyperuricemia increases the oxidative stress in the body and causes an adverse change in the rheological properties of rat erythrocytes. The blood is in a hyperviscosity and hypercoagulable state. The results suggest that clinical diagnosis and treatment of asymptomatic hyperuricemia correct understanding and timely intervention.