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目的探讨马杜霉素中毒的发病机制、临床表现及有效的治疗方法。方法回顾分析1例马杜霉素中毒患者的临床表现和实验室检查结果,并作文献复习。结果马杜霉素可经呼吸道、消化道、皮肤吸收,中毒早期可表现为肌肉疼痛、乏力、发热、大汗,严重者可表现为横纹肌溶解、急性肾功能衰竭、心力衰竭、中毒性神经炎和共济失调等神经系统损伤。结论及时血液净化和支持治疗是抢救的主要治疗措施,后期神经系统康复治疗也不容忽视。
Objective To investigate the pathogenesis, clinical manifestations and effective treatment of madupamycin intoxication. Methods A retrospective analysis of 1 case of patients with madupuyin poisoning clinical manifestations and laboratory tests, and literature review. Results Maduomycin can be absorbed through the respiratory tract, digestive tract and skin. Muscular pain, fatigue, fever and sweating may be manifested in early stage of poisoning. Rhabdomyolysis, acute renal failure, heart failure, toxic neuritis And ataxia and other nervous system damage. Conclusions Timely blood purification and supportive treatment are the main treatment measures for salvage, and the rehabilitation of nervous system should not be neglected.