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目的探究妊娠期单纯性低甲状腺激素血症对妊娠结果是否有不良影响。方法对112例诊断为妊娠期单纯性低甲状腺激素血症妇女和112例甲状腺功能正常妊娠妇女就多种因素进行比较。结果观察组和对照组两组之间就年龄、既往生育史、吸烟史、妊娠期感染史、妊娠期服药史等可能影响因素比较,发现其对妊娠结果无明显影响;两组间血清三碘甲状腺原氨酸(FT3)、促甲状腺激素(TSH)相比较,差异均无统计学意义;观察组与对照组平均血清甲状腺素水平分别为9.3±0.9μg/L、13.9±0.8μg/L,两组之间差异具有统计学意义(P<0.05)。在两组当中妊娠期间均未观察到流产、先兆子痫、胎盘早剥、早产等妊娠并发症。观察组新生儿出生时出平均出生体重值为3.2±0.2kg、平均身长49±1.3cm、平均头围33±1.7cm、新生儿评分(Apgar评分)平均值9.4±0.2,对照组新生儿平均出生体重3.0±0.3kg、平均身长50±0.9cm、平均头围34±0.9cm、Apgar评分平均值9.3±0.4,两组之间差异均无统计学意义。结论本研究发现妊娠期单纯性低甲状腺激素血症对妊娠没有不良影响。
Objective To investigate whether simple hypothyroidism during pregnancy has adverse effects on pregnancy outcome. Methods A total of 112 women diagnosed with gestational simple hypothyroidism and 112 women with normal thyroid function were compared for various factors. Results There was no significant difference between the observation group and the control group in terms of age, previous birth history, smoking history, history of pregnancy infection, medication history during pregnancy and so on. The serum triiodine Thyroid hormone (FT3) and thyrotropin (TSH), the mean thyroxine levels in the observation group and the control group were 9.3 ± 0.9μg / L and 13.9 ± 0.8μg / L respectively, The difference between the two groups was statistically significant (P <0.05). No pregnancy complications such as miscarriage, preeclampsia, placental abruption, premature labor were observed in either group during pregnancy. In the observation group, the average birth weight at birth was 3.2 ± 0.2 kg, the average length 49 ± 1.3 cm, the average head circumference 33 ± 1.7 cm and the average neonatal score (Apgar score) 9.4 ± 0.2. In the control group, the average neonatal average The birth weight was 3.0 ± 0.3kg, the average length was 50 ± 0.9cm, the average head circumference was 34 ± 0.9cm, and the average Apgar score was 9.3 ± 0.4. There was no significant difference between the two groups. Conclusions This study found that gestational simple hypothyroidism did not have adverse effects on pregnancy.