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目的研究痛得安散质量控制方法,以提高其质量标准。方法在原标准的基础上增加了痛得安散中羌活、丹参的TLC鉴别,改进了延胡索、黄芩、苍术的色谱条件;采用HPLC法对苍术素进行含量测定。结果 TLC法鉴别专属性强;HPLC法测得苍术素在2.0~24μg·ml-1范围内线性关系良好(r=0.9999),平均回收率为100.81%,RSD为1.67%(n=9)。结论本方法操作简单,结果准确,灵敏度高,重复性好;该质量标准可有效地控制痛得安散的质量。
Objective To study the pain control quality control methods to improve their quality standards. On the basis of the original standard, the method was added to the TLC identification of the pain of Rhizoma et Radix Notopterygii and Salvia miltiorrhiza and the chromatographic conditions of Rhizoma Corydalis, Scutellaria baicalensis and Cangzhu were improved. The content of atractylodes macrocephala was determined by HPLC. Results The TLC method was of high specificity. The correlation coefficient was between 2.0 ~ 24μg · ml-1 (r = 0.9999). The average recovery was 100.81% and the RSD was 1.67% (n = 9). Conclusion The method is simple, accurate, sensitive and repeatable. The quality standard can effectively control the quality of pain and relief.