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目的观察血必净注射液治疗儿童急性胰腺炎的临床疗效和治疗过程对炎症因子的影响,为临床提供理论依据。方法 57例儿童急性胰腺炎患者随机分为对照组(27例)和试验组(30例)。对照组给予常规治疗,试验组在常规治疗基础上,加用血必净注射液0.5~1ml·kg~(-1),每日1次,静脉滴注,疗程为7~10d。比较两组临床总有效率和临床症状消失时间、尿淀粉酶恢复正常时间、正常饮食时间和住院时间等基本指标,同时测定两组白细胞介素系列(IL-1、IL-6和IL-8)、肿瘤坏死因子α、C-反应蛋白和降钙素原等炎症因子水平。结果对照组和试验组的临床总有效率分别为63.0%和83.3%,试验组临床体症消失时间、血淀粉酶恢复正常时间、恢复正常饮食时间和住院时间均显著小于对照组,两组比较均有显著性差异(P<0.05)。治疗后,两组炎性因子均较治疗前显著下降,差异性比较有统计学意义(P<0.05),但试验组比对照组下降更显著(P<0.05)。试验组有2例出现轻微过敏反应,其余患者均未出现不良反应。结论血必净注射液可有效抑制儿童急性胰腺炎炎性因子释放,进而改善患者的预后,提高患者的治疗效果。
Objective To observe the clinical effect of Xuebijing injection on children with acute pancreatitis and the influence of the course of treatment on the inflammatory factors, so as to provide a theoretical basis for clinical practice. Methods 57 cases of children with acute pancreatitis were randomly divided into control group (27 cases) and experimental group (30 cases). The control group was given routine treatment. The experimental group was given Xuebijing injection 0.5-1ml · kg -1 once a day for 7-10 days on the basis of routine treatment. The clinical efficacy and disappearance of clinical symptoms, urinary amylase recovery time, normal diet time and hospital stay were compared between the two groups. The levels of IL-1, IL-6 and IL-8 ), Tumor necrosis factor alpha, C-reactive protein and calcitonin and other inflammatory cytokines. Results The total clinical effective rates of the control group and the experimental group were 63.0% and 83.3% respectively. The disappearance time of the clinical symptom, the recovery time of the blood amylase, the normal diet and the length of hospital stay in the experimental group were significantly less than those in the control group There was significant difference (P <0.05). After treatment, the two groups of inflammatory factors were significantly decreased compared with before treatment, the difference was statistically significant (P <0.05), but the experimental group decreased more significantly than the control group (P <0.05). Two patients in the test group had mild allergic reactions, and the remaining patients did not have any adverse reactions. Conclusion Xuebijing Injection can effectively inhibit the release of inflammatory factors in children with acute pancreatitis, thereby improving the prognosis of patients and improving the therapeutic effect of the patients.