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目的:研究老年糖尿病肾病(diabetic nephropathy,DN)采用肾康注射液治疗的有效性和安全性。方法:选取张家港市第一人民医院肾内科2013年1月至2015年6月收治的DN患者共70例,随机分为观察组和对照组。对照组予降糖、降血脂、ACEI/ARB降压等西医对症治疗,观察组在对照组治疗的基础上加用肾康注射液。对比两组患者治疗前后的肾功能、肌酐清除率、24 h尿蛋白、营养指标及肝功能。结果:治疗后观察组Scr、BUN、24 h尿蛋白、TC、TG、LDL-C及肢体困重、倦怠乏力、腰膝酸软、夜尿清长和食少纳呆等中医症状积分显著低于对照组(P<0.05),Hb、Alb、HDL-C显著高于对照组(P<0.05)。观察组患者治疗后均未发生三系下降、肝肾功能受损、心电图异常等不良反应,对照组患者治疗后出现白细胞<4.0×109/L 2例,肝功能损害1例,均于对症处理后好转。两组患者治疗前后ALT、AST、WBC差异无统计学意义(P>0.05)。结论:在西医治疗基础上,加用肾康注射液可有效改善老年DN患者的血糖与血脂、肾功能及临床症状,且具有较好安全性。
Objective: To study the efficacy and safety of Shenkang injection in the treatment of diabetic nephropathy (DN). Methods: Seventy patients with DN who were admitted to Department of Nephrology, First People’s Hospital of Zhangjiagang City from January 2013 to June 2015 were randomly divided into observation group and control group. The control group to hypoglycemic, hypolipidemic, ACEI / ARB antihypertensive Western medicine symptomatic treatment, the observation group in the control group based on the treatment with Shen Kang injection. The renal function, creatinine clearance rate, 24 h urine protein, nutrition index and liver function were compared between the two groups before and after treatment. Results: Urine protein, TC, TG, LDL-C, Scr, BUN, 24h urinary protein, fatigue, tiredness, weakness of waist and knees, Group (P <0.05), Hb, Alb, HDL-C were significantly higher than the control group (P <0.05). In the observation group, three series of descent, liver and kidney dysfunction, abnormal electrocardiogram and other adverse reactions did not occur after treatment. In the control group, there were 2 cases of leucocyte less than 4.0 × 109 / L and 1 case of liver dysfunction after symptomatic treatment After the improvement. There was no significant difference in ALT, AST and WBC between the two groups before and after treatment (P> 0.05). Conclusion: On the basis of western medicine treatment, adding Shenkang injection can effectively improve the blood sugar, blood lipid, renal function and clinical symptoms of elderly patients with DN, and has good safety.