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非小细胞肺癌 (NSCLC)是常见的恶性肿瘤 ,治疗效果不佳 ,有许多术中证实淋巴结阴性的患者仍在术后出现复发 ,这可能是由于存在常规病理手段无法发现的微转移病灶所导致。近年来 ,免疫组化和分子生物学方法已应用于外周血、骨髓及肿瘤附近淋巴结中微转移灶的检测 ,但是检测微转移灶的指标选择及临床意义目前仍有争论。作者讨论常见的检测NSCLC微转移的方法及检测结果的临床意义。
Non-small cell lung cancer (NSCLC) is a common malignant tumor with poor treatment outcome. Many patients with negative lymph nodes proved to have recurrence postoperatively, which may be caused by the presence of micrometastatic lesions that can not be found by routine pathology . In recent years, immunohistochemistry and molecular biology methods have been applied to the detection of micrometastases in peripheral blood, bone marrow and nearby lymph nodes. However, there are still controversies on the selection of indicators and the clinical significance of detecting micrometastases. The authors discuss the common detection of NSCLC micrometastasis and the clinical significance of test results.