新生隐球菌是一重要的致病真菌,其细胞壁外层的多糖荚膜是第1个被公认的新生隐球菌毒性因子。本文总结了在荚膜生理和生化合成方面的研究进展,介绍了研究新生隐球菌荚膜合成的常用方法以及在新生隐球菌的荚膜代谢途径、生化合成酶、分泌、组装和调节这些广泛的研究领域存在的许多未解决的问题 Cryptococcus neoformans is an important pathogenic fungus, the outer polysaccharide capsule of the cell wall is the first recognized virulence factor of C. neoformans. This article summarizes the advances in capsule physiology and biochemical synthesis and describes common methods for studying capsular synthesis of Cryptococcus neoformans as well as the capsular metabolic pathways, biochemical synthetases, secreted, assembled, and regulated these of Cryptococcus neoformans There are many unresolved issues in the field of research