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目的:比较两种梅毒血清免疫学检测方法的敏感性和特异性。方法:采用甲苯胺红不加热血清试验(TRUST)和梅毒螺旋体颗粒凝集试验(TP-PA)两种方法同时对69例梅毒患者的血液标本进行梅毒抗体检测。结果:两种方法检测的总阳性率差异无统计学意义(χ~2=1.73,P>0.05),TRUST方法在Ⅰ期和Ⅲ期梅毒的阳性率分别为85.4%和66.7%,Ⅱ期梅毒为100%;TP-PA方法除在Ⅰ期梅毒时阳性率为92.7%,其他各期都达到了100.0%。结论:根据流行病学史,结合临床实际,可采用任何一类梅毒血清免疫学检测方法作为筛查试验,然后用不同原理的血清免疫学检测方法来做确认试验。
OBJECTIVE: To compare the sensitivity and specificity of two methods of immunological detection of syphilis. Methods: Totally 69 syphilis patients were tested for syphilis antibodies by TRUST and TP-PA methods. Results: The positive rates of TRUST in stage Ⅰ and stage Ⅲ syphilis were 85.4% and 66.7%, respectively. There was no significant difference between the two methods (χ ~ 2 = 1.73, P> 0.05) Was 100%. The positive rate of TP-PA except for the first stage syphilis was 92.7%, the other stages reached 100.0%. Conclusion: According to the epidemiological history, combined with clinical practice, any type of syphilis serum immunological test can be used as a screening test, and then use different principles of serum immunological test to confirm the test.