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目的 探讨血小板参数在急性水肿型胰腺炎 (AEP)和出血坏死性胰腺炎 (AHNP)中的变化特点及生长抑素 (SS)对其影响。方法 应用血细胞自动分析仪检测AEP和AHNP病人不同时期血小板计数 (PLT) ,平均血小板体积 (MPV)和血小板分布宽度 (PDW )。结果 AEP患者血小板参数无明显变化 ,1周后 ,PLT无明显升高 ,MPV和PDW有显著性升高 (P <0 .0 5 ) ;常规治疗后 ,对血小板参数无影响 ;SS治疗后 ,MPV和PDW有显著性升高 (P <0 .0 5 )。而AHNP患者PLT显著降低 (P <0 .0 5 ) ,MPV和PDW有显著性升高 (P <0 .0 5 ) ,1周后PLT显著性升高 (P <0 .0 5 ) ,但MPV和PDW无明显降低 ;常规治疗后 ,PLT升高 ,MPV、PDW均降低 (P <0 .0 5 ) ;SS治疗后PLT显著性升高 (P <0 .0 5 ) ,MPV、PDW无明显变化。结论 AEP与AHNP患者血小板参数的变化有明显不同 ,可反映病情变化。SS治疗后 ,对PLT无影响 ,但可增加血小板的活性 ,对AHNP患者有一定的治疗和预防作用
Objective To investigate the changes of platelet parameters in acute edematous pancreatitis (AEP) and hemorrhagic necrotizing pancreatitis (AHNP) and the effect of somatostatin (SS) on it. Methods The platelet count (PLT), mean platelet volume (MPV) and platelet distribution width (PDW) in different stages of AEP and AHNP were detected by automatic blood analyzer. Results There was no significant change of platelet parameters in AEP patients. After 1 week, there was no significant increase in PLT, MPV and PDW were significantly increased (P <0.05); after treatment, platelet parameters had no effect; after SS treatment, MPV and PDW were significantly increased (P <0.05). PLT was significantly decreased in AHNP patients (P <0.05), MPV and PDW were significantly increased (P <0.05), PLT was significantly increased in 1 week (P <0.05) MPV and PDW had no significant reduction. After treatment, PLT increased, MPV and PDW decreased (P <0.05), PLT increased significantly after SS treatment (P <0.05), MPV and PDW had no significant difference obvious change. Conclusion The changes of platelet parameters in AEP and AHNP patients are obviously different, which can reflect the changes of the disease. SS treatment, no effect on PLT, but increased platelet activity, AHNP patients have a certain therapeutic and preventive effect