本文综述了小檗碱(Ber)在人、兔、狗、大鼠、小鼠体内的药动学资料。肠胃道对Ber有相当量的吸收,达峰所需时间较短,在体内分布快和广,且在多数组织器官内的药物浓度高于血药浓度,可通过血-胎盘屏障。由于Ber在胆汁内有高浓度分布,似乎存在着肝肠循环。Ber在人体内滞留时间较长。Ber先被脱亚甲基或脱甲基,随后形成硫酸酯排出体外。Beriv主要从尿排出,Berig主要由粪便排出。 This article reviews the pharmacokinetics of berberine in humans, rabbits, dogs, rats and mice. The gastrointestinal tract has a considerable amount of Ber absorption, peak time is shorter, faster and wider distribution in the body, and in most tissues and organs of the drug concentration is higher than the plasma concentration, through the blood - placental barrier. Because Ber has a high concentration of bile distribution, it seems there is enterohepatic circulation. Ber stays longer in the body. Ber is first demethlylated or demethylated, followed by sulfate formation to excrete it. Beriv is mainly excreted from the urine, while Berig is excreted mainly from the excrement.