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目的分析HSP70、HSP90在肾细胞癌组织中表达的意义。方法用免疫组化S-P法检测32例肾细胞癌组织标本中HSP70、HSP90的表达情况。结果肾细胞癌组织中HSP70、HSP90表达阳性率分别为90.6%(29/32)、84.4%(27/32),明显高于正常肾组织,差异有统计学意义(P<0.05);但其表达程度与肾细胞癌临床分期及细胞类型无明显相关性(P>0.05)。结论HSP70、HSP90高表达在肾细胞癌的发生、发展中具有促进作用。
Objective To analyze the expression of HSP70 and HSP90 in renal cell carcinoma. Methods Immunohistochemical S-P method was used to detect the expression of HSP70 and HSP90 in 32 cases of renal cell carcinoma. Results The positive rates of HSP70 and HSP90 in renal cell carcinoma tissues were 90.6% (29/32) and 84.4% (27/32), respectively, which were significantly higher than those in normal renal tissues (P <0.05) There was no significant correlation between the expression level and the clinical stage and cell type of renal cell carcinoma (P> 0.05). Conclusion High expression of HSP70 and HSP90 may promote the occurrence and development of renal cell carcinoma.