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目的：探讨增殖细胞核抗原（ＰｒｏｌｉｆｅｒａｔｉｎｇＣｅｌＮｕｃｌｅａｒＡｎｔｉｇｅｎ，ＰＣＮＡ）与鼻咽癌（ＮＰＣ）临床生物学行为及预后的关系。方法：所有患者的疗前鼻咽活检标本，用ＰＣＮＡ抗体进行ＳＰ法免疫组化染色，阳性程度分为四级：０、＋、＋＋和＋＋＋级。结果：ＰＣＮＡ的阳性程度与ＮＰＣ的Ｔ、Ｎ分期、临床分期及放疗结束时颈结残留无关，与肿瘤复发和转移呈极显著性正相关（Ｐ＜０．０１）。结论：ＰＣＮＡ可作为对ＮＰＣ预后的判断及指导临床治疗的指标。
Objective: To investigate the relationship between Proliferating Cell Nuclear Antigen (PCNA) and clinical biological behavior and prognosis of nasopharyngeal carcinoma (NPC). METHODS: Preoperative nasopharyngeal biopsy specimens of all patients were immunohistochemically stained with SPNA using PCNA antibody. The positive degree was divided into four levels: 0, +, ++ and +++. RESULTS: The positive degree of PCNA was not associated with the N, T, N stage, clinical stage, and neck knots at the end of radiotherapy. It was significantly positively correlated with tumor recurrence and metastasis (P<0.01). Conclusion: PCNA can be used as an indicator to judge the prognosis of NPC and guide clinical treatment.