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目的观察新城疫病毒(NDV)对裸鼠人肺癌移植瘤的抗肿瘤作用。方法建立人肺腺癌细胞系spc-a-1在裸小鼠皮下移植瘤动物模型,瘤体内1次注射NDV病毒作抗肿瘤研究,同时设PBS对照,观察6周,绘制肿瘤生长曲线,比较两组肿瘤体积变化。结果NDV组肿瘤生长迟缓,PBS组肿瘤生长迅速,6周后PBS组瘤重明显大于NDV组(P<0·01)。结论NDV对裸小鼠人肺腺癌移植瘤有明显的抑制作用。
Objective To observe the antitumor effect of Newcastle disease virus (NDV) on human lung cancer xenografts in nude mice. Methods The human lung adenocarcinoma cell line spc-a-1 was subcutaneously transplanted in nude mice. The tumor cells were injected with NDV virus once for antitumor study. PBS control group was also established. The growth curve of the cells was observed for 6 weeks. Tumor volume changes in both groups. Results The tumor growth was slow in NDV group. The tumor growth in PBS group was rapid. After 6 weeks, the tumor weight in PBS group was significantly greater than that in NDV group (P <0.01). Conclusion NDV has a significant inhibitory effect on human lung adenocarcinoma xenografts in nude mice.