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目的了解吉林省乙型肝炎病毒(HBV)的基因型流行及分布情况,探讨HBV基因型与其预防治疗的临床意义。方法采用多对型特异性引物套式聚合酶链反应(nest-PCR)对吉林省194份HBV阳性血清进行分型,并研究HBV与预防和治疗的关系。结果在194例HBV血清阳性标本中,B型16例,C型172例,B、C混合型6例,未发现其它型别的病毒。结论在吉林省HBV的基因型主要为C型,B、C混合型也占了一定比例。C型与肝硬化和肝癌关系密切,混合型与慢性肝炎关系密切。
Objective To understand the prevalence and distribution of hepatitis B virus (HBV) in Jilin Province and to explore the clinical significance of HBV genotypes and its prevention and treatment. Methods 194 HBV positive sera from Jilin Province were genotyped by using multi-pair specific primer set-type PCR (nest-PCR), and the relationship between HBV and prevention and treatment was studied. Results Of the 194 HBV seropositive specimens, 16 were type B, 172 were type C, 6 were mixed with type B and C. No other type of virus was found. Conclusion The genotypes of HBV in Jilin Province are mainly C type, while the B and C mixed types account for a certain proportion. C type and liver cirrhosis and liver cancer are closely related, mixed and chronic hepatitis are closely related.