MF1小鼠实验感染曼氏血吸虫尾蚴1周、3周和6周后，分别经肺静脉和门静脉灌注取虫。虫体被置于含有不同剂量环孢素A和药物代谢产物的199型培养液中培养。实验显示，药物体外抗曼氏血吸虫的作用呈时间、剂量和虫龄依赖方式；童虫和雄虫对药物更敏感。本结果表明，环孢素A具有直接杀曼氏血吸虫的活性，并可导致虫体病理学改变。 MF1 mice experimentally infected with Schistosoma mansoni cercariae 1 week, 3 weeks and 6 weeks later, respectively, by pulmonary vein and portal vein to take the worm. The worms were cultured in 199 medium containing different doses of cyclosporine A and drug metabolites. Experiments show that the drug in vitro anti-Schistosoma mansoni role in time, dosage and age dependent manner; sperm and male insects are more sensitive to drugs. The results show that cyclosporin A has the activity of directly killing Schistosoma mansoni and can cause pathological changes of parasites.