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目的：探讨一种阳性率更高的实验指标，以提高重症肌无力的实验室诊断率。方法：将α一银环蛇毒素和β－银环蛇毒素混合一起包被酶标板，结合随后加的肌肉提取液中相应蛋白质为抗原，以ＡＢＣ－ＥＬＩＳＡ法检测重症肌无力病人血清中混合的抗乙酰胆碱受体抗体（ＡｃｈＲａｂ）和抗突触前膜受体抗体（ＰｓｍＲａｂ），称为抗突触受体抗体。结果：７５名正常人均阴性。８０例临床对照组中，除２例运动神经元疾病和１例多发性肌炎阳性外，其余均阴性。本组１２２例重症肌无力病人中９８例阳性（８０．３％，其中全身型阳性８７．５％），阳性率明显高于单独检测ＡｃｈＲａｂ，（Ｐ＜０．００１）。结论：检测抗突触受体抗体可作为重症肌无力诊断的一个阳性率较高的较好的实验室指标。
Objective: To explore a higher positive rate of experimental indicators to improve the laboratory diagnosis of myasthenia gravis. Methods: Alpha-bungarotoxin and beta-bungarotoxin were mixed with a microtiter plate and then the corresponding proteins in the muscle extracts were added as antigens to detect the serum mixed with myasthenia gravis by ABC-ELISA Of anti-acetylcholine receptor antibody (AchRab) and anti-presynaptic membrane receptor antibody (PsmRab), known as anti-synaptosome antibodies. Results: 75 normal people were negative. 80 cases of clinical control group, except for 2 cases of motor neuron disease and 1 case of polymyositis positive, the rest were negative. The group of 122 patients with myasthenia gravis 98 cases were positive (80.3%, including 87.5% of the total body positive), the positive rate was significantly higher than the separate test AchRab, (P <0.001). Conclusion: The detection of anti-synaptosomal antibody can be used as a good laboratory test for the diagnosis of myasthenia gravis.