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目的对抗抑郁药的使用情况进行统计分析,了解用药现状,为临床合理用药提供依据。方法采用限定日剂量法,对2014年5月份使用抗抑郁药病人的基本信息,及抗抑郁药的用药金额、用药频度(DDDs)、日均费用(DDC)等指标进行统计分析。结果新型抗抑郁药在临床应用更为广泛,新型抗抑郁药联合第二代抗精神病药常用于治疗伴抑郁症状的精神分裂症、伴精神病性症状的抑郁症或分裂样情感障碍等疾病。结论依据抗抑郁药的药效学和药动学的特点,参考更多循证医学证据,使抗抑郁药在临床中应用趋于个体化。
Objective To analyze the use of antidepressants and to understand the status quo of drug use in order to provide a basis for clinical rational drug use. Methods The daily dose method was used to analyze the basic information of antidepressants in May 2014, the amount of antidepressants, DDDs, DDC and other indicators. Results The new antidepressants are more widely used in clinical practice. The new antidepressants combined with the second generation antipsychotics are often used to treat schizophrenia with depression, depression with psychotic symptoms or schizoaffective disorder. Conclusion Based on the pharmacodynamic and pharmacokinetic characteristics of antidepressants, more evidence-based medicine is used to make antidepressants more individualized in clinical practice.