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目的通过检测88例新疆东部子痫前期妇女胎盘中水通道蛋白9(Aquaporin9 AQP9),为进一步揭示子痫前期病因奠定基础。方法通过免疫组化,ELISA等方法对88例新疆东部不同病变程度的子痫前期妇女胎盘中AQP9进行定量分析,揭示AQP9的表达与病变的相关程度。结果 AQP9在88例妊娠妇女胎盘中有不同程度的表达,20例正常妊娠妇女的表达程度显著低于68例子痫前期的妇女,34例轻度子痫前期的妇女AQP9的表达程度显著低于34例重度子痫前期及子痫妇女(P<0.05)。结论 AQP9在新疆东部子痫前期妇女胎盘的表达与疾病严重程度具有正相关性,为子痫前期预测研究奠定基础。
Objective To detect the placental aquaporin 9 AQP9 in 88 cases of preeclampsia in eastern part of Xinjiang for the purpose of further revealing the cause of preeclampsia. Methods Quantitative analysis of AQP9 in placenta of 88 preeclampsia women with different pathological changes in eastern Xinjiang by immunohistochemistry, ELISA and other methods revealed the correlation between the expression of AQP9 and the pathological changes. Results The expression of AQP9 in 88 pregnant women with different degrees of placenta expression was significantly lower in 20 normal pregnant women than in 68 preeclampsia women. The expression of AQP9 in 34 mild preeclampsia women was significantly lower than 34 Cases of severe preeclampsia and eclampsia women (P <0.05). Conclusion The positive expression of AQP9 in the placenta of women with preeclampsia in eastern Xinjiang is positively correlated with the severity of the disease, which lays the foundation for the prediction of preeclampsia.