十年前,Sela首先提出了合成疫苗的设想,但反应并不强烈。近年来,随着基础理论和分子生物学研究的深入,合成肽链疫苗在理论和实践上均取得了较大进展。一、合成疫苗与传统疫苗传统的免疫接种基于诱导与自然感染相似的免疫力。其诱导的免疫反应范围(Immunological repertoire)不大可能超过病毒的自然感染。合成疫苗是合成的某些抗原决定簇的相应结构实体。在自然感染中,这些抗原决定簇可诱导免疫反应,亦可不诱导免疫 Ten years ago, Sela first proposed the idea of ​​a synthetic vaccine, but the reaction was not strong. In recent years, with the deepening of basic theory and molecular biology, synthetic peptide chain vaccine has made great progress both in theory and in practice. First, the synthetic vaccine and traditional vaccination Traditional immunization is based on the induction of immunity similar to natural infection. Its induced immune response range (Immunological repertoire) is unlikely to exceed the natural infection of the virus. Synthetic vaccines are the corresponding structural entities for the synthesis of certain antigenic determinants. In natural infection, these epitopes can induce an immune response, may not induce immunity