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目的：测定并比较２种用于预防新生儿眼炎的药物的体外抗菌活性。方法：采用肉汤二倍稀释法测定最低抑菌浓度和最低杀菌浓度。结果：硝酸银滴眼液对新生儿眼炎常见致病菌金葡菌、肺炎球菌与淋球菌的ＭＩＣ５０为＜４～８μｇ·ｍｌ－１，ＭＢＣ９０为８～３２μｇ·ｍｌ－１；聚维酮碘滴眼液对受试菌的ＭＩＣ５０为６４～２５６μｇ·ｍｌ－１，ＭＢＣ９０为５１２μｇ·ｍｌ－１。结论：硝酸银滴眼液和聚维酮碘滴眼液对新生儿眼炎常见致病菌都具抑菌和杀菌作用，但硝酸银作用更强
Objective: To determine and compare the in vitro antibacterial activity of two drugs for the prevention of neonatal ophthalmia. Methods: The minimum inhibitory concentration and the minimum bactericidal concentration were determined by double dilution method of broth. Results: The MIC50 of silver nitrate eye drops on S. aureus, pneumococcus and Neisseria gonorrhoeae were less than 4 ~ 8μg · ml-1 and 8 ~ 32μg · ml-1 for MBC90, respectively. Povidone The iodine eye drops had MIC50 of 64 ~ 256μg · ml-1 and MBC90 of 512μg · ml-1. CONCLUSION: Silver nitrate eye drops and povidone-iodine eye drops have antibacterial and bacteriostatic effects on the common pathogens of neonatal ophthalmia, but the effect of silver nitrate is stronger