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目的观察乌司他丁治疗急性胰腺炎的临床疗效及安全性。方法将80例急性胰腺炎患者随机分为观察组42例和对照组38例,对照组给予常规治疗,观察组在常规治疗基础上加用乌司他丁。观察两组治疗前后临床指标的变化。结果治疗后观察组的腹痛持续时间、胰腺体积恢复时间、血淀粉酶恢复正常时间、平均住院时间均短于对照组(P均<0.05),观察组的总有效率显著高于对照组(P<0.05),观察组的并发症发生率显著低于对照组(P<0.05)。结论乌司他丁治疗急性胰腺炎安全有效,并能减少并发症。
Objective To observe the clinical efficacy and safety of ulinastatin in the treatment of acute pancreatitis. Methods Eighty patients with acute pancreatitis were randomly divided into observation group (n = 42) and control group (n = 38). The control group was given routine treatment. The observation group was given ulinastatin on the basis of routine treatment. The changes of clinical indexes before and after treatment were observed. Results After treatment, the duration of abdominal pain, the recovery time of pancreatic volume, the recovery time of serum amylase and the average length of hospital stay in the observation group were shorter than those in the control group (all P <0.05). The total effective rate in the observation group was significantly higher than that in the control group <0.05). The incidence of complication in the observation group was significantly lower than that in the control group (P <0.05). Conclusion Ulinastatin is safe and effective in the treatment of acute pancreatitis and can reduce the complications.