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目的:探讨肝细胞生长因子(HGF)在糖尿病肾病(DN)患者血清中的作用及临床价值。方法:92例2型糖尿病(T2DM)患者按尿白蛋白肌酐比(ACR)分为三组:单纯糖尿病组(简称为A组,30例),微量蛋白尿组(简称为B组,30例),大量蛋白尿组(简称为C组,32例),选择正常健康者50例为对照组,采用自动分析仪测定HGF、空腹血糖(FBG)、血甘油三醋(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)水平。结果:与对照组比较,2型糖尿病各组患者血清HGF、FBG、HDL水平显著升高(P<0.05);B组与A组比较、C组与B组比较患者血清HGF、FBG水平显著上升(P<0.05);TG、LDL水平在各组间比较差异无统计学意义。相关性分析结果表明,HGF水平与FBG、HDL水平呈显著正相关(r=0.619,0.373;P=0.000,0.012),HGF水平与TG、LDL水平无相关性(r=0.071,0.018;P=0.782,0.893)。结论:HGF可作为DN发生和发展的重要指标,检测HGF有利于早期DN的诊断和治疗。
Objective: To investigate the role and clinical value of hepatocyte growth factor (HGF) in the serum of patients with diabetic nephropathy (DN). Methods: 92 patients with type 2 diabetes mellitus (T2DM) were divided into three groups according to urinary albumin creatinine ratio (ACR): simple diabetic group (A group, 30 cases), microalbuminuria group (abbreviated as group B, 30 cases ), A large number of proteinuria group (referred to as C group, 32 cases), 50 normal healthy subjects were selected as the control group. HGF, fasting blood glucose (FBG), triglyceride (TG), low density lipids Protein (LDL), high density lipoprotein (HDL) levels. Results: Compared with the control group, the levels of serum HGF, FBG and HDL in patients with type 2 diabetes mellitus were significantly increased (P <0.05); Compared with those in patients in group A, the serum HGF and FBG levels in patients in group C and B were significantly increased (P <0.05). There was no significant difference in TG and LDL between the two groups. The results of correlation analysis showed that there was a significant positive correlation between HGF level and FBG and HDL levels (r = 0.619,0.373; P = 0.000,0.012), HGF level had no correlation with TG and LDL levels (r = 0.071,0.018; P = 0.782,0.893). Conclusion: HGF can be used as an important index for the occurrence and development of DN. Detection of HGF is beneficial to the diagnosis and treatment of early DN.