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目的：研究ｐｏ安克干糖浆后羟氨苄青霉素与克拉维酸的药动学与生物利用度。方法：采用离子对反相高效液相色谱法测定１０名健康志愿受试者ｐｏ安克干糖浆和Ａｕｇｍｅｎｔｉｎ干糖浆后，轻氨苄青霉素与克拉维酸在血中浓度变化情况，计算二者的药动学参数、相对生物利用度，并以双单侧ｔ检验法进行统计分析。结果：二者羟氨苄青霉素的药－时数据用统计矩方法处理，达峰时间分别是８５．１±５．４２ｍｉｎ与８３．１±９．８８ｍｉｎ，峰浓度分别是１０．９４±０．７２μｇ／ｍｌ与１０．８８±０．５５μｇ／ｍｌ，平均滞留时间分别是１４０．３７±１２．６１ｍｉｎ与１３１．０５±１１．０６ｍｉｎ，药－时曲线下面积分别是１５６６．２５±１２８．４７（μｇ·ｍｉｎ）／ｍｌ与１４６４．３７±１１５．４５（μｇ，ｍｉｎ）／ｍｌ。二者克拉维酸的药－时曲线符合一级吸收的一室模型，达峰时间分别是６４．３１±４．６２ｍｉｎ与６３．３±２．７６ｍｉｎ，药－时曲线下面积分别是４８８．５６±４１．０５（μｇ·ｍｉｎ）／ｍｌ与４８８．９６±２５．２６（μｇ·ｍｉｎ）／ｍｌ，安克干糖浆相对生物利用度羟氨苄青霉素是１０８．２０％±１４．２０％，克拉维酸是９９．８３％±５．１０％?
OBJECTIVE: To study the pharmacokinetics and bioavailability of amoxicillin and clavulanic acid after po Anker dry syrup. Methods: Ion-pair reversed-phase high-performance liquid chromatography was used to determine the concentration changes of light ampicillin and clavulanic acid in 10 healthy volunteers po pokegan and syndromycin, Kinematics parameters, relative bioavailability, and double unilateral t test for statistical analysis. Results: The drug-time data of amoxicillin were both processed by statistical moment method, the peak time was 85.1 ± 5.42min and 83.1 ± 9.88min respectively, the peak concentrations were 10.94 ± 0.72μg / Ml and 10.88 ± 0.55μg / ml, the average retention time was 140.37 ± 12.61min and 131.05 ± 11.06min, the area under the drug-time curve was 1566.25 ± 128.47 ( μg · min) / ml and 1464.37 ± 115.45 (μg, min) / ml. The pharmacokinetics of clavulanic acid coincided with the first-order absorption model of one-compartment model. The peak time was 64.31 ± 4.62min and 63.3 ± 2.76min respectively, and the area under the drug-time curve was 488. 56 ± 41.05 (μg · min) / ml and 488.96 ± 25.26 (μg · min) / ml, the relative bioavailability of Ankang syrup was amoxicillin was 108.20% ± 14.20% Clavulanic acid is 99.83% ± 5.10%?