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现今已经发展了三种磷酸抗生素:磷霉素(fosfomycin),磷酰胺霉素(fosmidomycin)和alafosfalin.前两个化合物有相似的作用机制,即抑制细菌细胞壁合成起始步骤中的磷酸丙酮酸盐转移酶.它是第一种磷酸抗生素,并且使用非肠道剂型,特别在欧洲更是如此.近来其使用指征有所增加.直到现在因受到肠道吸收、血和尿中浓度很低的限制其钙盐及赖氨酸盐口服剂型还不很成功.一种新的水溶性的磷霉素与fromethamine(2-氨基-2-羟甲基
Three phosphate antibiotics have now been developed: fosfomycin, fosmidomycin and alafosfalin. The first two compounds have a similar mechanism of action that inhibits the phosphorylation of pyruvate in the initial steps of bacterial cell wall synthesis It is the first phosphate antibiotic and is used in parenteral dosage forms, especially in Europe, and has recently shown an increase in its use. Until now, it has been shown to be very low in blood and urine due to intestinal absorption Limiting the oral dosage form of its calcium and lysine salts has not been successful.A new water-soluble fosfomycin is associated with fromethamine (2-amino-2-hydroxymethyl