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目的观察多巴胺联合酚妥拉明治疗全身炎症反应综合征所致小儿腹胀的临床治疗效果。方法 48例由全身炎症反应综合征所致腹胀的患儿,随机分为对照组(20例)和治疗组(28例)。对照组予以常规治疗,治疗组在对照组的基础上联合多巴胺、酚妥拉明治疗,比较两组临床疗效。结果对照组患儿总有效率为75%(15/20),低于治疗组的96%(27/28),差异有统计学意义(χ~2=4.898,P<0.05)。对照组患儿腹胀消失时间为(5.7±1.2)d,平均住院时间为(6.1±0.8)d;治疗组患儿的腹胀消失时间为(3.7±0.6)d,平均住院时间为(4.2±0.4)d,两组比较差异均有统计学意义(P<0.05)。结论多巴胺联合酚妥拉明治疗全身炎症反应综合征所致小儿腹胀效果明显,可改善患儿临床症状,缩短住院时间,具有临床应用意义。
Objective To observe the clinical effect of dopamine combined with phentolamine in treatment of infantile bloating caused by systemic inflammatory response syndrome. Methods Forty-eight children with abdominal distension caused by systemic inflammatory response syndrome were randomly divided into control group (20 cases) and treatment group (28 cases). The control group was given routine treatment. The treatment group was treated with dopamine and phentolamine on the basis of the control group, and the clinical curative effect was compared between the two groups. Results The total effective rate was 75% (15/20) in the control group, which was lower than 96% (27/28) in the treatment group. The difference was statistically significant (χ ~ 2 = 4.898, P <0.05). In the control group, the disappearance time of abdominal distension was (5.7 ± 1.2) days and the average length of hospital stay was (6.1 ± 0.8) days. The duration of abdominal distension and disappearance in the treatment group was (3.7 ± 0.6) days and the average length of hospital stay was (4.2 ± 0.4) ) d, the difference between the two groups was statistically significant (P <0.05). Conclusion Dopamine combined with phentolamine treatment of systemic inflammatory response syndrome caused by obvious abdominal distension in children can improve clinical symptoms and shorten the length of hospital stay, with clinical significance.