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胰腺神经内分泌肿瘤的发病率逐年增加，科学制订治疗决策有助于改善病人生存。手术切除是治疗胰腺神经内分泌肿瘤的主要手段，尤其是局限性肿瘤。目前国内外关于无功能性胰腺神经内分泌肿瘤外科治疗的观点仍存在争议，笔者结合国内外文献和临床实践，对相关争议进行梳理，强调制订手术方案时，需综合考虑病人年龄、体力状况，肿瘤部位、分期、分级和功能状态。依据病人具体情况，尊重循证医学证据，真正实现胰腺神经内分泌肿瘤的个体化治疗。“,”The incidence of pancreatic neuroendocrine tumors is increasing in recent years. Scientific treatment strategy will improve the prognosis of patients. Surgical resection is the main treatment for pancreatic neuroendocrine tumors, especially for localized tumors. At present, there are still controversies about the treatment of pancreatic neuroendocrine tumors at home and abroad. Based on the literature and clinical practice, the author combs the related controversies and suggests that the age, physical condition, tumor location, staging, grading and functional status of the patients should be taken into consideration when making the surgical plan. The individualized treatment of pancreatic neuroendocrine tumor should be realized according to the specific situation of the patients and the evidence-based medicine.