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目的观察血清脑钠肽(BNP)、C反应蛋白(CRP)和尿酸(UA)浓度的变化与冠状动脉(冠脉)病变之间的关系。方法临床拟诊冠心病患者146例,冠脉病变的严重程度分别用冠脉病变的血管支数、冠脉狭窄程度和冠脉病变积分表示。按冠脉造影结果分为冠脉正常组(27例)、单支病变组(32例)、双支病变组(48例)和多支病变组(39例),均于入院时测定血清中BNP、CRP和UA水平,进行统计分析。结果冠脉狭窄程度积分多支病变组(94.46±34.35)分高于双支病变组(48.84±19.07)分高于单支病变组(27.83±10.33)分高于冠脉正常组(3.11±1.98)分(P<0.05);各冠脉病变患者组BNP、CRP及UA水平均明显高于冠脉正常组,且随着病变支数的增多,三者浓度逐渐增高;BNP、CRP及UA水平与冠脉狭窄程度积分(Gensini法)呈正相关(P<0.05);冠脉病变患者中的BNP、CRP及UA水平三者呈正相关(P<0.05)。结论 BNP、CRP和UA与冠心病关系密切,三者联合检测可反映冠状动脉病变情况,可预测冠状动脉病变严重程度,评估患者病情。
Objective To observe the relationship between the changes of serum brain natriuretic peptide (BNP), C-reactive protein (CRP) and uric acid (UA) and coronary artery (coronary artery) lesions. Methods 146 cases of clinically diagnosed patients with coronary heart disease, the severity of coronary artery lesions were used coronary vessel count, coronary artery stenosis and coronary artery disease score points. According to coronary angiography results were divided into normal coronary artery group (27 cases), single lesion group (32 cases), double-vessel lesion group (48 cases) and multivessel disease group (39 cases) BNP, CRP and UA levels, for statistical analysis. Results The score of coronary stenosis score multi-vessel disease group (94.46 ± 34.35) was higher than that of double-vessel disease group (48.84 ± 19.07), higher than that of single vessel disease group (27.83 ± 10.33), higher than that of coronary artery group (3.11 ± 1.98 ) (P <0.05). The levels of BNP, CRP and UA in all the patients with coronary artery disease were significantly higher than those in normal coronary artery group. The levels of BNP, CRP and UA increased with the increase of the number of lesions (P <0.05). There was a positive correlation between BNP, CRP and UA in patients with coronary artery disease (P <0.05). Conclusions BNP, CRP and UA are closely related to coronary heart disease. The combined detection of these three factors can reflect the severity of coronary artery disease and predict the severity of coronary artery disease.